2,4-Difluoronitrobenzene → HCID 18422166, compound

HRID 1281765Notes

Reaction equation

HRID 1281765 reaction equation
[NH2:1][C:2]1[S:6][C:5]2[CH:7]=[C:8]([O:11][CH3:12])[CH:9]=[CH:10][C:4]=2[C:3]=1[C:13]([O:15][CH2:16][CH3:17])=[O:14].F[C:19]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=1[N+:26]([O-:28])=[O:27]>CS(C)=O>[F:25][C:23]1[CH:22]=[CH:21][C:20]([N+:26]([O-:28])=[O:27])=[C:19]([CH:24]=1)[NH:1][C:2]1[S:6][C:5]2[CH:7]=[C:8]([O:11][CH3:12])[CH:9]=[CH:10][C:4]=2[C:3]=1[C:13]([O:15][CH2:16][CH3:17])=[O:14]

Participants

4

Reactant 2

HCID 679672,4-DifluoronitrobenzeneHCID 18422175HCID 18422175, compound

Product 1

HCID 18422166HCID 18422166, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

In the same manner as in Starting Material Synthesis Example 4 and using ethyl 2-amino-6-methoxybenzo[b]thiophene-3-carboxylate, 2,4-difluoronitrobenzene and dimethyl sulfoxide, ethyl 2-(5-fluoro-2-nitroanilino)-6-methoxybenzo[b]thiophene-3-carboxylate is obtained.

Workup

  1. customMaterial Synthesis Example 4

Sources & evidence

ORD record
ord-9a6d2d9b366444dca939fb39882a64d9
Source dataset
uspto-grants-2002_09
Patent number
US06455521B1

Reaction notes

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