HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-(4-methyl-2-nitroanilino)benzo[b]thiophene-3-carboxylate → Ethyl 2-(2-amino-4-methylanilino)benzo[b]thiophene-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-(4-methyl-2-nitroanilino)benzo[b]thiophene-3-carboxylate | HCID 18422341 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Ethyl 2-(2-amino-4-methylanilino)benzo[b]thiophene-3-carboxylate | HCID 18422219 | 62.2% |
Reaction Steps
In the same manner as in Starting Material Synthesis Example 19 and using ethyl 2-(4-methyl-2-nitroanilino)benzo[b]thiophene-3-carboxylate (6.5 g), ethyl acetate (140 ml), 10% palladium-carbon and hydrogen (500 mg, 60 atm kg/cm2), ethyl 2-(2-amino-4-methylanilino)benzo[b]thiophene-3-carboxylate (3.7 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06455521B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-04a1c81b31914773af8efba41f784a6b |
| Source note | uspto-grants-2002_09 |