HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 18422345, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2,5-Dichloronitrobenzene | HCID 6977 | — |
| Reactant | Stannous chloride dihydrate | HCID 61436 | — |
| Reactant | Ethyl 2-amino-1-benzothiophene-3-carboxylate | HCID 699464 | — |
| Reactant | HCID 18422303 | HCID 18422303 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 18422345 | HCID 18422345 | — |
Reaction Steps
In the same manner as in Starting Material Synthesis Example 4 and using ethyl 2-aminobenzo[b]thiophene-3-carboxylate (6.0 g), 2,5-dichloronitrobenzene (5.8 g) and dimethyl sulfoxide (70 ml), crude crystals (9.5 g) of ethyl 2-(4-chloro-2-nitroanilino)benzo[b]thiophene-3-carboxylate were obtained. Without purification, in the same manner as in Starting Material Synthesis Example 21 and using ethanol (100 ml), 18% hydrochloric acid (100 ml) and tin(II) chloride dihydrate (22.5 g), ethyl 2-(2-amino-4-chloroanilino)benzo[b]thiophene-3-carboxylate (3.0 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06455521B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-35b79bb5c6814b0a94cc5dcfd6e18e62 |
| Source note | uspto-grants-2002_09 |