HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ethyl 2-(2-amino4,5-dichloroanilino)benzo[b]thiophene-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2,4,5-Trichloronitrobenzene | HCID 6983 | — |
| Reactant | Stannous chloride dihydrate | HCID 61436 | — |
| Reactant | Ethyl 2-amino-1-benzothiophene-3-carboxylate | HCID 699464 | — |
| Reactant | Ethyl 2-(4,5-dichloro-2-nitroanilino)benzo[b]thiophene-3-carboxylate | HCID 18422321 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 2-(2-amino4,5-dichloroanilino)benzo[b]thiophene-3-carboxylate | HCID 18422259 | — |
Reaction Steps
In the same manner as in Starting Material Synthesis Example 4 and using ethyl 2-aminobenzo[b]thiophene-3-carboxylate (6.0 g), 2,4,5-trichloronitrobenzene (6.8 g) and dimethyl sulfoxide (70 ml), crude crystals (10.3 g) of ethyl 2-(4,5-dichloro-2-nitroanilino)benzo[b]thiophene-3-carboxylate were obtained. Without purification, in the same manner as in Starting Material Synthesis Example 21 and using ethanol (100 ml), 18%hydrochloric acid (100 ml) and tin(II) chloride-dihydrate (22.8 g), ethyl 2-(2-amino-4,5-dichloroanilino)benzo[b]thiophene-3-carboxylate (5.3 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06455521B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-ded1db50a42441b69d876a3bf4465b91 |
| Source note | uspto-grants-2002_09 |