HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → 9-methyl-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | Ethyl 2-(2-amino-4-methylanilino)benzo[b]thiophene-3-carboxylate | HCID 18422219 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | Anisole | HCID 7519 | — |
| Product | 9-methyl-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine | HCID 135816409 | — |
Reaction Steps
In the same manner as in Example 1 and using ethyl 2-(2-amino-4-methylanilino)benzo[b]thiophene-3-carboxylate (3.7 g), 1-methylpiperazine (19 ml), anisole (60 ml) and titanium tetrachloride (3.0 ml), 9-methyl-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine (1.18 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06455521B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-2e82e6fea9ec435b9fe1350596de5b54 |
| Source note | uspto-grants-2002_09 |