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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1281801Generated: October 26, 2026

Anisole → 8,9-difluoro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine

https://huagongshe.com/reaction/1281801

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAnisoleHCID 7519—
Reactant1-MethylpiperazineHCID 53167—
ReactantEthyl 2-(2-amino-4,5-difluoroanilino)benzo[b]thiophene-3-carboxylateHCID 18422150—
CatalystTitanium TetrachlorideHCID 24193—
Product8,9-difluoro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepineHCID 135816405—

Reaction Steps

In the same manner as in Example 1 and using ethyl 2-(2-amino-4,5-difluoroanilino)benzo[b]thiophene-3-carboxylate, 1-methylpiperazine, anisole and titanium tetrachloride, 8,9-difluoro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine is obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06455521B1
Source datasetuspto-grants-2002_09
ORD IDord-d53b12cb02f146048619f630e18c4ca8
Source noteuspto-grants-2002_09