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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1281802Generated: October 30, 2026

Anisole → HCID 18422176, compound

https://huagongshe.com/reaction/1281802

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAnisoleHCID 7519—
Reactant1-MethylpiperazineHCID 53167—
ReactantHCID 18422356HCID 18422356—
CatalystTitanium TetrachlorideHCID 24193—
ProductHCID 18422176HCID 18422176—

Reaction Steps

In the same manner as in Example 1 and using ethyl 2-(2-amino-3,5-difluoroanilino)benzo[b]thiophene-3-carboxylate, 1-methylpiperazine, anisole and titanium tetrachloride, 8,10-difluoro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine is obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06455521B1
Source datasetuspto-grants-2002_09
ORD IDord-9218fe1e02a24627b28ea6ea82aad96f
Source noteuspto-grants-2002_09