HuagongsheHuagongshe Chemistry Print Report · For research reference only
Anisole → 3-methyl-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Anisole | HCID 7519 | — |
| Reactant | Ethyl 2-(2-aminoanilino)-6-methylbenzo[b]thiophene-3-carboxylate | HCID 18422261 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | 1-Methylpiperazine | HCID 53167 | — |
| Product | 3-methyl-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine | HCID 135816403 | — |
Reaction Steps
In the same manner as in Example 1 and using ethyl 2-(2-aminoanilino)-6-methylbenzo[b]thiophene-3-carboxylate (3.7 g), 1-methylpiperazine (80 ml), anisole (16 ml) and titanium tetrachloride (3 ml), 3-methyl-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine (1.4 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06455521B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-7a57cdb9d9f4483ab20e940e89c68af4 |
| Source note | uspto-grants-2002_09 |