2,4-Difluoronitrobenzene → HCID 18422344, compound

HRID 1281811Notes

Reaction equation

HRID 1281811 reaction equation
[NH2:1][C:2]1[S:6][C:5]2[CH:7]=[C:8]([O:11][CH3:12])[CH:9]=[CH:10][C:4]=2[C:3]=1[C:13]#[N:14].F[C:16]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=1[N+:23]([O-:25])=[O:24]>>[CH3:12][O:11][C:8]1[CH:9]=[CH:10][C:4]2[C:3]([C:13]#[N:14])=[C:2]([NH:1][C:16]3[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=3[N+:23]([O-:25])=[O:24])[S:6][C:5]=2[CH:7]=1

Participants

3

Reactant 2

HCID 679672,4-DifluoronitrobenzeneHCID 184222202-Amino-6-methoxy-1-benzothiophene-3-carbonitrile

Product 1

HCID 18422344HCID 18422344, compoundYield 29%

Procedure

In the same manner as in Starting Material Synthesis Example 51 and using 2-amino-6-methoxybenzo[b]thiophene-3-carbonitrile (5.2 g) and 2,4-difluoro-nitrobenzene (4.0 g), 6-methoxy-2-(5-fluoro-2-nitroanilino)benzo[b]thiophene-3-carbonitrile (2.5 g) was obtained.

Workup

  1. customMaterial Synthesis Example 51

Sources & evidence

ORD record
ord-23116e2740d245dc8f8d3dcb88849fd0
Source dataset
uspto-grants-2002_09
Patent number
US06455521B1

Reaction notes

Loading…