HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene, 2-fluoro-4-methyl-1-nitro- → 6-Fluoro-2-(5-methyl-2-nitroanilino)benzo[b]thiophene-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| Reactant | 2-Amino-6-fluorobenzo[b]thiophene-3-carbonitrile | HCID 18422184 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 6-Fluoro-2-(5-methyl-2-nitroanilino)benzo[b]thiophene-3-carbonitrile | HCID 18422235 | 88.1% |
Reaction Steps
In the same manner as in Starting Material Synthesis Example 51 and using 2-amino-6-fluorobenzo[b]thiophene-3-carbonitrile (5.0 g), 3-fluoro-4-nitrotoluene (4.7 g) and dimethyl sulfoxide (55 ml), 6-fluoro-2-(5-methyl-2-nitroanilino)benzo[b]thiophene-3-carbonitrile (7.5 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06455521B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-78a8c42e08214c1c8cc1585b38597dea |
| Source note | uspto-grants-2002_09 |