HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-methylphenol → 2-bromo-4,5,6,7-tetrahydro-N-(2-hydroxy-4-methylphenyl)-benzo[b]thiophene-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-methylphenol | HCID 76082 | — |
| Reactant | 2-Bromo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid | HCID 18422137 | — |
| Solvent | Thionyl Chloride | HCID 24386 | — |
| Product | 2-bromo-4,5,6,7-tetrahydro-N-(2-hydroxy-4-methylphenyl)-benzo[b]thiophene-3-carboxamide | HCID 18422208 | 68.9% |
Reaction Steps
In the same manner as in Starting Material Synthesis Example 60 and using 2-bromo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (6 g), thionyl chloride (30 ml), 2-amino-5-methylphenol (3.14 g), 2-bromo-4,5,6,7-tetrahydro-N-(2-hydroxy-4-methylphenyl)-benzo[b]thiophene-3-carboxamide (5.8 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06455521B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-367cd89ed591487685587ca52050b533 |
| Source note | uspto-grants-2002_09 |