Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1281842Generated: November 2, 2026

N,N-Dimethylaniline → 8-Fluoro-12-(4-methylpiperazin-1-yl)-[1]benzothieno[2,3-b][1,5]benzoxazepine

https://huagongshe.com/reaction/1281842

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN,N-DimethylanilineHCID 949—
ReactantPhosphorus oxychlorideHCID 24813—
Reactant1-MethylpiperazineHCID 53167—
Reactant8-fluoro-[1]benzothieno[2,3-b][1,5]benzoxazepin-12(11H)-oneHCID 18422264—
Product8-Fluoro-12-(4-methylpiperazin-1-yl)-[1]benzothieno[2,3-b][1,5]benzoxazepineHCID 18422206—

Reaction Steps

In the same manner as in Example 80 and using 8-fluoro-[1]benzothieno[2,3-b][1,5]benzoxazepin-12(11H)-one, phosphorus oxychloride, N,N-dimethylaniline and 1-methylpiperazine, 8-fluoro-12-(4-methylpiperazin-1-yl)-[1]benzothieno[2,3-b][1,5]benzoxazepine is obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06455521B1
Source datasetuspto-grants-2002_09
ORD IDord-9f893b8a942d43b6aa2556d02b672936
Source noteuspto-grants-2002_09