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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1281871Generated: October 25, 2026

Potassium Carbonate → 8-fluoro-2-methylthieno[2,3-b][1,5]benzoxazepin-4(5H)-one

https://huagongshe.com/reaction/1281871

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
ReactantN-(4-fluoro-2-hydroxyphenyl)-2-bromo-5-methyl-3-thiophenecarboxamideHCID 18422331—
Product8-fluoro-2-methylthieno[2,3-b][1,5]benzoxazepin-4(5H)-oneHCID 18422316—

Reaction Steps

Similar reaction is carried out using N-(4-fluoro-2-hydroxyphenyl)-2-bromo-5-methyl-3-thiophenecarboxamide and potassium carbonate to give 8-fluoro-2-methylthieno[2,3-b][1,5]benzoxazepin-4(5H)-one.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06455521B1
Source datasetuspto-grants-2002_09
ORD IDord-ef0bcd8b2ec14574941d07def1390d75
Source noteuspto-grants-2002_09