反应详情

2-Formylthieno[2,3-b][1,5]benzoxazepin-4(5H)-one (1.6 g) was suspended in methanol (30 ml) and sodium borohydride (480 mg) was added. The mixture was stirred at room temperature for 1.5 hours. The reaction mixture was diluted with water and extracted 3 times with chloroform. The organic layer was dried over sodium sulfate and the solvent was evaporated under reduced pressure. To the residue were added chloroform and diisopropyl ether and the precipitated crystals were collected by filtration to give 2-hydroxymethylthieno[2,3-b][1,5]benzoxazepin-4(5H)-one (1.0 g).

1. extractionextracted 3 times with chloroform
2. dry with materialThe organic layer was dried over sodium sulfate
3. customthe solvent was evaporated under reduced pressure
4. additionTo the residue were added chloroform and diisopropyl ether
5. filtrationthe precipitated crystals were collected by filtration