HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Dimethylaniline → 2-Methyl-4-(4-methylpiperazin-1-yl)-7-nitrothieno[2,3-b][1,5]benzoxazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Dimethylaniline | HCID 949 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 2-methyl-7-nitrothieno[2,3-b][1,5]benzoxazepin-4(5H)-one | HCID 18422144 | — |
| Product | 2-Methyl-4-(4-methylpiperazin-1-yl)-7-nitrothieno[2,3-b][1,5]benzoxazepine | HCID 18422192 | — |
Reaction Steps
In the same manner as in Example 125 and using 2-methyl-7-nitrothieno[2,3-b][1,5]benzoxazepin-4(5H)-one, phosphorus oxychloride, N,N-dimethylaniline and 1-methylpiperazine, 2-methyl-4-(4-methylpiperazin-1-yl)-7-nitrothieno[2,3-b][1,5]benzoxazepine is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06455521B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-226b04b79edf4253b85c76d3ed3a6f35 |
| Source note | uspto-grants-2002_09 |