HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-Methoxyphenyl)methyl-3-methyl-4-piperidone → 2-(2-Methoxyphenyl)methyl-3-methyl-4-methylene-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-Methoxyphenyl)methyl-3-methyl-4-piperidone | HCID 11075321 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Catalyst | Methyltriphenyliphosphonium bromide | HCID 74505 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(2-Methoxyphenyl)methyl-3-methyl-4-methylene-piperidine | HCID 10998856 | — |
Reaction Steps
20.1 g (56 mmol) of methyl-triphenylphosphonium bromide, 6.3 g (56 mmol) of potassium tert-butoxide and 11 g (47 mmol) of 2-(2-methoxyphenyl)methyl-3-methyl-4-piperidone 15 in 200 mL of abs. THF are used. The product is crystallized from acetone as the oxalate. Yield: 13.1 g (87%); melting point: 145° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06455538B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-6f228702070a4f38ab0f85ccc0710ffb |
| Source note | uspto-grants-2002_09 |