Butyl Formate → N-formyl-2-(2-methoxyphenyl)methyl-3-methyl-4-methylene-piperidine
Reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH:10]1[CH:15]([CH3:16])[C:14](=[CH2:17])[CH2:13][CH2:12][NH:11]1.[CH2:18]([O:22]C=O)CCC>>[CH:18]([N:11]1[CH2:12][CH2:13][C:14](=[CH2:17])[CH:15]([CH3:16])[CH:10]1[CH2:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[O:2][CH3:1])=[O:22]Participants
3
Procedure
8 g (34 mmol) of 2-(2-methoxyphenyl)methyl-3-methyl-4-methylene-piperidine 16 as base and 30 mL of n-butylformate were used. Yield: 9.1 g (100%) as an oil.
Sources & evidence
- ORD record
- ord-1e63ca7db4cc498587990b03f6e97986
- Source dataset
- uspto-grants-2002_09
- Patent number
- US06455538B1
Reaction notes
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