HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-Aminonicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-{[(Tert-butoxy)carbonyl]amino}pyridine-3-carboxylic acid | HCID 22172623 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Aminonicotinic acid | HCID 319979 | — |
Reaction Steps
A mixture of 4-(N-t-butoxycarbonylamino)nicotinic acid (2.72 g, 11.4 mmol), TFA (10 mL), and CH2Cl2 (20 mL) is stirred at room temperature for 12 h. The volatiles are removed under reduced pressure, and the resulting crude 4-amino nicotinic acid is used directly in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06455534B2 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-f28ae5e3b9764bcab2804e3869caafe6 |
| Source note | uspto-grants-2002_09 |