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HRID1281962

反应详情

EQUATION

反应方程式

HRID 1281962 的结构方程式

REACTANTS

反应物

3
结构：O=C=O
HCID280

Carbon dioxide

CO2

结构：CC(C)(C)OC(=O)Nc1ccc(F)nc1
HCID11031143

tert-Butyl (6-fluoropyridin-3-yl)carbamate

C10H13FN2O2

结构：[Li]CCCC
HCID178418339

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)Nc1cnc(F)cc1C(=O)O
HCID10611065

5-[(tert-Butoxycarbonyl)amino]-2-fluoropyridine-4-carboxylic acid

C11H13FN2O4

收率 25%

PROCEDURE

实验过程

Reaction of 5-[N-(tert-butoxycarbonyl)amino]-2-fluoropyridine (5.3 g, 25 mmol) sequentially with n-BuLi and CO2 as described in the following example gives 5-[N-(tert-butoxycarbonyl)amino]-2-fluoropyridine-4-carboxylic acid (1.60 g, 25%). 1H NMR (DMSO) δ 9.83 (1H, brs), 8.84 (1H, s), 7.49 (1H, d, J=2.9 Hz), 1.47 (9H, s).