HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 5-Amino-2-fluoroisonicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 5-((tert-Butoxycarbonyl)amino)-2-fluoroisonicotinic acid | HCID 10611065 | — |
| Product | 5-Amino-2-fluoroisonicotinic acid | HCID 2762511 | 75.6% |
Reaction Steps
Reaction of 5-[N-(tert-butoxycarbonyl)amino]-2-fluoropyridine-4-carboxylic acid (1.0 g, 3.9 mmol) with TFA as described above gives 5-amino-2-fluoropyridine-4-carboxylic acid(0.46 g, 74%). 1H NMR (DMSO) δ 7.85 (1H, d, J=1.5 Hz), 7.23 (1H, d, J=2.5 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06455534B2 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-e7eea88c1c744cffa3307a5c890d3652 |
| Source note | uspto-grants-2002_09 |