HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethyl phosphite → 4-(Dimethoxy-phosphorylmethyl)-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethyl phosphite | HCID 8472 | — |
| Reactant | Methyl 4-(bromomethyl)benzoate | HCID 256687 | — |
| Product | 4-(Dimethoxy-phosphorylmethyl)-benzoic acid methyl ester | HCID 10801170 | — |
Reaction Steps
Methyl 4-(bromomethyl) benzoate (compound 47) (11.2 g, 49 mmol) was dissolved in 25 mL trimethyl phosphite and refluxed under N2 for 5 hrs. Excess trimethyl phosphite was removed by co-distillation with toluene to give crude 4-(Dimethoxy-phosphorylmethyl)-benzoic acid methyl ester (compound 48).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06455545B2 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-4af4eaa1c5ff434f92a67eb54a92f19a |
| Source note | uspto-grants-2002_09 |