Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | HCID 18374741 | HCID 18374741 | — |
| Catalyst | Chlorotris(triphenylphosphine)rhodium(I) | HCID 84599 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 18423463 | HCID 18423463 | — |
Reaction Steps
A mixture of 3.5 g (15.7 mmol) of 1-allyl-3-(SR)-hydroxymethyl-4-(RS)-(3-thienyl)pyrrolidine and 400 mg (0.43 mmol) of Wilkinson's catalyst [Rh(PPh3)3Cl] in 200 mL of an 85% solution of CH3CN and water was heated to 90° C. and stirred for 3 h. The reaction mixture was cooled to rt and concentrated to give the title compound which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06455548B2 |
|---|
| Source dataset | uspto-grants-2002_09 |
|---|
| ORD ID | ord-2d3c2b7a74fa4c208c2cf4b3ba712bc3 |
|---|
| Source note | uspto-grants-2002_09 |
|---|
