Pyridine → HCID 70117622, compound

Participants

Reaction Steps

A solution of 0.02 g (0.04 mmol) of 1-(2,4-dichlorobenzyl)-3-(S)-(4-(3-hydroxypropyloxymethyl)piperidinylmethyl)-4-(S)-(3-thienyl)pyrrolidine (Example 17), 0.25 mL (0.12 mmol) of acetic anhydride, 0.25 mL (0.3 mmol) of pyridine and a catalytic amount of DMAP in 0.5 mL of CH2Cl2 was stirred at rt for 2 h. TO the reaction mixture was added 10 mL of sat'd Na2CO3 solution and it was extracted with CH2Cl2. The combined organic layers were dried over MgSO4, filtered and the filtrate was concentrated. The residue was purified by chromatography (silica, hexanes:ethyl acetate, 1:1) to give the title compound. Mass Spectrum (ESI) m/e=539 (M+1 35Cl, 35Cl), 541 (M+1 35Cl, 37Cl), and 543 (M+1 37Cl, 37Cl).

Provenance & Evidence