Pyridine → HCID 10165709, compound

Participants

Reaction Steps

A solution of 0.03 g (0.06 mmol) of 1-(2,4-dichlorobenzyl)-3-(S)-(4-(3-aminopropyloxymethyl)piperidinylmethyl)-4-(S)-(3-thienyl)pyrrolidine, 0.02 mL (0.12 mmol) of acetic anhydride, 0.025 mL (0.3 mmol) of pyridine and a catalytic amount of DMAP in 0.5 mL of CH2Cl2 was stirred at rt for 18 h. The reaction mixture was concentrated and the residue was purified by chromatography (silica, CH2Cl2:methanol, 9:1) to give the title compound. Mass Spectrum (ESI) m/e=538 (M+1 35Cl, 35Cl), 540 (M+1 35Cl, 37Cl), and 542 (M+1 37Cl, 37Cl).

Provenance & Evidence