反应详情

Tetrabutylammonium fluoride (12 ml,1M in tetrahydrofuran) was added to a stirred solution of 4-(tert-butyldimethylsilanyloxy)-1-(7-methoxybenzofuran-2-yl)-butan-1-ol (4 g) in tetrahdrofuran (50 ml) at 0° C. After stirring cooled for 2 hours the reaction was warmed to room temperature and allowed to stir for a further 1 hour. The solvent was removed in vacuo and the residue partitioned between ethyl acetate (100 ml) and water (50 ml). The organic extract was dried over magnesium sulphate, filtered and preadsorbed onto silica. Purification by column chromatography on silica eluting with ethyl acetate yielded the title compound as a tan oil (2.34 g).

1. temperaturecooled for 2 hours the reaction
2. stirringto stir for a further 1 hour
3. customThe solvent was removed in vacuo
4. customthe residue partitioned between ethyl acetate (100 ml) and water (50 ml)
5. extractionThe organic extract
6. dry with materialwas dried over magnesium sulphate
7. filtrationfiltered
8. customPurification by column chromatography on silica eluting with ethyl acetate