反应详情

A solution of 7-methoxy-2-methoxymethylbenzofuran (13.32 g) in acetonitrile (500 ml) was stirred at room temperature. N-bromosuccinimide (11.04 g) was added and stirring continued for 2 days after which the solvent was removed in vacuo. The resulting oil was partitioned between ethyl acetate (100 ml) and sodium metasulfite solution (50 ml), the organic extract washed with more sodium metasulfite solution (2×50 ml), followed by brine (50 ml). The organic layer was separated, dried over magnesium sulphate, filtered and the solvent removed in vacuo to afford the title compound as a yellow oil (18.61 g).

1. customafter which the solvent was removed in vacuo
2. customThe resulting oil was partitioned between ethyl acetate (100 ml) and sodium metasulfite solution (50 ml)
3. extractionthe organic extract
4. washwashed with more sodium metasulfite solution (2×50 ml)
5. customThe organic layer was separated
6. dry with materialdried over magnesium sulphate
7. filtrationfiltered
8. customthe solvent removed in vacuo