2-Methyl-2H-pyrazol-3-ylamine → HCID 9922879, compound

HRID 1282042Notes

Reaction equation

HRID 1282042 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:15]([OH:17])=O)=[C:7]2[C:11]=1[O:10][C:9]([CH2:12][O:13][CH3:14])=[CH:8]2.[CH3:18][N:19]1[C:23]([NH2:24])=[CH:22][CH:21]=[N:20]1>>[CH3:18][N:19]1[C:23]([NH:24][C:15]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[C:11]3[O:10][C:9]([CH2:12][O:13][CH3:14])=[CH:8][C:7]=23)=[O:17])=[CH:22][CH:21]=[N:20]1

Participants

3

Reactant 2

HCID 1369272-Methyl-2H-pyrazol-3-ylamineHCID 18423641HCID 18423641, compound

Product 1

HCID 9922879HCID 9922879, compoundYield 34.6%

Procedure

Starting from 7-methoxy-2-methoxymethylbenzofuran-4-carboxylic acid (93 mg) and 2-methyl-2H-pyrazol-3-ylamine (40 mg). Purification by column chromatography on silica eluting with ethyl acetate afforded the title compound as a white solid (43 mg).

Workup

  1. customPurification by column chromatography on silica eluting with ethyl acetate

Sources & evidence

ORD record
ord-575963320c6447e88c335ca632b80493
Source dataset
uspto-grants-2002_09
Patent number
US06455561B1

Reaction notes

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