Thionyl Chloride → N-((4-(chloromethyl)phenyl)methyl)acetamide

HRID 1282049Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1282049
O[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][NH:10][C:11](=[O:13])[CH3:12])=[CH:5][CH:4]=1.S(Cl)([Cl:16])=O>C(Cl)(Cl)Cl>[Cl:16][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][NH:10][C:11](=[O:13])[CH3:12])=[CH:5][CH:4]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 15550683N-(4-(hydroxymethyl)benzyl)acetamide

Produkt 1

HCID 15550682N-((4-(chloromethyl)phenyl)methyl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

To a solution of N-(4-hydroxymethylphenylmethyl)acetamide (1.5 g) in chloroform (50 ml) was added thionyl chloride (0.73 ml) and the mixture was refluxed under heating for 1 hr. The solvent was evaporated and the obtained residue was crystallized from ethyl acetate to give the title compound (1.8 g) as pale-yellow crystals.

Aufarbeitung

  1. temperaturethe mixture was refluxed
  2. temperatureunder heating for 1 hr
  3. customThe solvent was evaporated
  4. customthe obtained residue was crystallized from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-0c7d81dfc33e4dad9e5e8384eff8668c
Quelldatensatz
uspto-grants-2002_09
Patentnummer
US06455528B1

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