HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 1-[2-(2,6-Dimethyl-phenoxy)ethyl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-(2-Bromoethoxy)-1,3-dimethylbenzene | HCID 2452208 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 1-[2-(2,6-Dimethyl-phenoxy)ethyl]piperazine | HCID 23468652 | — |
Reaction Steps
To methylethylketone (1 liter) are added 2-(2,6-dimethylphenoxy)-1-bromo-ethane (132 g), sodium iodide (85 g), potassium carbonate (80 g) and piperazine (200 g). The mixture is refluxed for 24 hours, with stirring. After cooling, the mixture is filtered and then washed with 3×300 ml benzene. After evaporation of the benzene, the piperazine derivative is distilled; b.p. 25 mm Hg=190° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04259334 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-81ef5e212bdb488faab82b396a9fc6ad |
| Source note | uspto-grants-1981_03 |