反应详情

温度

0 °C

To a solution of 1-(4-chloromethylphenyl)ethanol (17 g) in acetonitrile (102 ml) was added dropwise conc. sulfuric acid (5.7 ml) under ice-cooling. The mixture was stirred at 0° C. for 3.5 hr and left standing overnight. The reaction mixture was poured into water and extracted with ethyl acetate. The extract was washed with an aqueous sodium hydrogencarbonate solution and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated to give a white solid. This solid was recrystallized from ethyl acetate-isopropyl ether to give the title compound (17 g) as white crystals.

1. temperaturecooling
2. waitleft
3. waitstanding overnight
4. extractionextracted with ethyl acetate
5. washThe extract was washed with an aqueous sodium hydrogencarbonate solution and saturated brine
6. dry with materialdried over anhydrous magnesium sulfate
7. customThe solvent was evaporated
8. customto give a white solid
9. customThis solid was recrystallized from ethyl acetate-isopropyl ether