1-(2,4-Difluorophenyl)piperazine dihydrochloride → HCID 11494507, compound

HRID 1282090Notes

Reaction equation

HRID 1282090 reaction equation
Cl.Cl.[F:3][C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:5]=1[N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.Cl[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([CH:25]([NH:27][C:28](=[O:30])[CH3:29])[CH3:26])=[CH:21][CH:20]=1>>[F:3][C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:5]=1[N:11]1[CH2:12][CH2:13][N:14]([CH2:18][C:19]2[CH:20]=[CH:21][C:22]([CH:25]([NH:27][C:28](=[O:30])[CH3:29])[CH3:26])=[CH:23][CH:24]=2)[CH2:15][CH2:16]1

Participants

3

Reactant 2

HCID 141267451-(2,4-Difluorophenyl)piperazine dihydrochlorideHCID 18423033N-(1-(4-chloromethylphenyl)ethyl)acetamide

Product 1

HCID 11494507HCID 11494507, compound

Procedure

By similar reaction and treatment to that in Example 1(5) using 1-(2,4-difluorophenyl)piperazine dihydrochloride instead of phenylpiperazine and N-(1-(4-chloromethylphenyl)ethyl)acetamide instead of N-(4-chloromethylphenylmethyl)acetamide, the title compound was obtained as white crystals, m.p.=109-111° C.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-2bcdaf9b428c434ab829a5580649aa81
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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