1-(4-Fluorophenyl)piperazine dihydrochloride → HCID 11696104, compound

HRID 1282105Notes

Reaction equation

HRID 1282105 reaction equation
Cl.Cl.[F:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1.Cl[CH:17]([C:19]1[CH:24]=[CH:23][C:22]([CH2:25][NH:26][C:27](=[O:29])[CH3:28])=[CH:21][CH:20]=1)[CH3:18]>>[F:3][C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:15][CH2:14][N:13]([CH:17]([C:19]3[CH:24]=[CH:23][C:22]([CH2:25][NH:26][C:27](=[O:29])[CH3:28])=[CH:21][CH:20]=3)[CH3:18])[CH2:12][CH2:11]2)=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 162119161-(4-Fluorophenyl)piperazine dihydrochlorideHCID 18423036N-(4-(1-chloroethyl)phenylmethyl)acetamide

Product 1

HCID 11696104HCID 11696104, compound

Procedure

By similar reaction and treatment to that in Example 1(5) using 1-(4-fluorophenyl)piperazine dihydrochloride instead of phenylpiperazine and N-(4-(1-chloroethyl)phenylmethyl)acetamide instead of N-(4-chloromethylphenylmethyl) acetamide, the title compound was obtained as white crystals, m.p.=128-130° C.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-3a23c6d34df547a4846d1a328507f473
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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