Hydrochloric Acid → N-[1-[4-(1-Hydroxyethyl)phenyl]-1-methylethyl]acetamide

Participants

Reaction Steps

To a solution of N-(1-(4-acetylphenyl)-1-methylethyl)acetamide (50.0 g) in methanol (400 ml) was added dropwise sodium borohydride (4.3 g) at below 5° C. over 30 min. The mixture was stirred at room temperature for 2 hr and 2N hydrochloric acid (60 ml) was added. The mixture was treated by a conventional method and the obtained crude crystals were recrystallized from ethanol to give the title compound (42.17 g) as white crystals.

Provenance & Evidence