1-(4-Fluorophenyl)piperazine dihydrochloride → Methyl 1-(4-((4-(4-fluorophenyl)piperazin-1-yl)methyl)phenyl)cyclopropanecarboxylate

HRID 1282109Notes

Reaction equation

HRID 1282109 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:12]([O:14][CH3:15])=[O:13])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.Cl.Cl.[F:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[CH:21][CH:20]=1>>[F:18][C:19]1[CH:20]=[CH:21][C:22]([N:25]2[CH2:30][CH2:29][N:28]([CH2:2][C:3]3[CH:8]=[CH:7][C:6]([C:9]4([C:12]([O:14][CH3:15])=[O:13])[CH2:11][CH2:10]4)=[CH:5][CH:4]=3)[CH2:27][CH2:26]2)=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 162119161-(4-Fluorophenyl)piperazine dihydrochlorideHCID 18423090Methyl 1-(4-chloromethylphenyl)cyclopropanecarboxylate

Product 1

HCID 18422997Methyl 1-(4-((4-(4-fluorophenyl)piperazin-1-yl)methyl)phenyl)cyclopropanecarboxylate

Procedure

By similar reaction and treatment to that in Example 1(5) using methyl 1-(4-chloromethylphenyl)cyclopropanecarboxylate obtained in Example 75(2) instead of N-(4-chloromethylphenylmethyl)acetamide and 1-(4-fluorophenyl)piperazine dihydrochloride instead of phenylpiperazine, the title compound was obtained as a pale-yellow oil.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-931f3e623aeb45aaa67eafe43e3dcc1b
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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