1-(4-Fluorophenyl)piperazine dihydrochloride → HCID 18423134, compound

HRID 1282113Notes

Reaction equation

HRID 1282113 reaction equation
Cl[CH:2]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2([NH:13][C:14](=[O:16])[CH3:15])[CH2:12][CH2:11]2)=[CH:6][CH:5]=1)[CH3:3].Cl.Cl.[F:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[CH:22][CH:21]=1>>[F:19][C:20]1[CH:21]=[CH:22][C:23]([N:26]2[CH2:31][CH2:30][N:29]([CH:2]([C:4]3[CH:9]=[CH:8][C:7]([C:10]4([NH:13][C:14](=[O:16])[CH3:15])[CH2:12][CH2:11]4)=[CH:6][CH:5]=3)[CH3:3])[CH2:28][CH2:27]2)=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 162119161-(4-Fluorophenyl)piperazine dihydrochlorideHCID 18423114HCID 18423114, compound

Product 1

HCID 18423134HCID 18423134, compound

Procedure

By similar reaction and treatment to that in Example 1(5) using N-(1-(4-(1-chloroethyl)phenyl)cyclopropyl)acetamide instead of N-(4-chloromethylphenylmethyl)acetamide and 1-(4-fluorophenyl)piperazine dihydrochloride instead of phenylpiperazine, the title compound was obtained as white crystals, m.p.=149-150° C.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-f9b80d9217974be687536b0a140fca59
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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