1-(2-Pyrimidinyl)piperazine → HCID 11500997, compound

HRID 1282125Notes

Reaction equation

HRID 1282125 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.Cl[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([CH:21]([NH:23][C:24](=[O:26])[CH3:25])[CH3:22])=[CH:17][CH:16]=1>>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:12][CH2:11][N:10]([CH2:14][C:15]2[CH:16]=[CH:17][C:18]([CH:21]([NH:23][C:24](=[O:26])[CH3:25])[CH3:22])=[CH:19][CH:20]=2)[CH2:9][CH2:8]1

Participants

3

Reactant 2

HCID 887471-(2-Pyrimidinyl)piperazineHCID 18423033N-(1-(4-chloromethylphenyl)ethyl)acetamide

Product 1

HCID 11500997HCID 11500997, compound

Procedure

By similar reaction and treatment to that in Example 1(5) using 1-(2-pyrimidyl)piperazine instead of phenylpiperazine and N-(1-(4-chloromethylphenyl)ethyl)acetamide obtained in Example 66(3) instead of N-(4-chloromethylphenylmethyl)acetamide, the title compound was obtained as white crystals.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-1a32389298ca466caa4ae5c100ecc345
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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