2-Piperazinylpyrimidine dihydrochloride → HCID 11566790, compound

HRID 1282126Notes

Reaction equation

HRID 1282126 reaction equation
Cl[CH:2]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2([NH:13][C:14](=[O:16])[CH3:15])[CH2:12][CH2:11]2)=[CH:6][CH:5]=1)[CH3:3].Cl.Cl.[N:19]1[CH:24]=[CH:23][CH:22]=[N:21][C:20]=1[N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[N:19]1[CH:24]=[CH:23][CH:22]=[N:21][C:20]=1[N:25]1[CH2:30][CH2:29][N:28]([CH:2]([C:4]2[CH:9]=[CH:8][C:7]([C:10]3([NH:13][C:14](=[O:16])[CH3:15])[CH2:12][CH2:11]3)=[CH:6][CH:5]=2)[CH3:3])[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 116802722-Piperazinylpyrimidine dihydrochlorideHCID 18423114HCID 18423114, compound

Product 1

HCID 11566790HCID 11566790, compound

Procedure

By similar reaction and treatment to that in Example 1(5) using N-(1-(4-(1-chloroethyl)phenyl)cyclopropyl)acetamide instead of N-(4-chloromethylphenylmethyl)acetamide and 1-(2-pyrimidyl)piperazine dihydrochloride instead of phenylpiperazine, the title compound was obtained as white crystals, m.p.=124-125° C.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-4305a62ec05c4c91afd15dedd3cf050e
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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