2-Piperazinylpyrimidine dihydrochloride → HCID 9798551, compound

HRID 1282128Notes

Reaction equation

HRID 1282128 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([NH:12][C:13](=[O:15])[CH3:14])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.Cl.Cl.[N:18]1[CH:23]=[CH:22][CH:21]=[N:20][C:19]=1[N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>>[N:18]1[CH:23]=[CH:22][CH:21]=[N:20][C:19]=1[N:24]1[CH2:29][CH2:28][N:27]([CH2:2][C:3]2[CH:8]=[CH:7][C:6]([C:9]3([NH:12][C:13](=[O:15])[CH3:14])[CH2:11][CH2:10]3)=[CH:5][CH:4]=2)[CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 116802722-Piperazinylpyrimidine dihydrochlorideHCID 18423039N-(1-(4-chloromethylphenyl)cyclopropyl)acetamide

Product 1

HCID 9798551HCID 9798551, compound

Procedure

By similar reaction and treatment to that in Example 1(5) using N-(1-(4-chloromethylphenyl)cyclopropyl)acetamide instead of N-(4-chloromethylphenylmethyl)acetamide and 1-(2-pyrimidyl)piperazine dihydrochloride instead of phenylpiperazine, the title compound was obtained as white crystals, m.p.=145-146° C.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-e2af70237a70495aa59bc6b7748bef7b
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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