Water → 1-(6-fluoropyridin-2-yl)piperazine

HRID 1282146Notes

Reaction equation

HRID 1282146 reaction equation
C([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[N:11]=2)[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+].O>CO>[F:16][C:12]1[N:11]=[C:10]([N:7]2[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]2)[CH:15]=[CH:14][CH:13]=1

Participants

5

Reactant 3

HCID 962Water2×HCID 14798Sodium HydroxideHCID 184230931-Acetyl-4-(6-fluoropyridin-2-yl)piperazine

Product 1

HCID 37288181-(6-fluoropyridin-2-yl)piperazineYield 103%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 1-acetyl-4-(6-fluoropyridin-2-yl)piperazine (5.5 g) and sodium hydroxide (3.0 g) in methanol (30 ml)—water (30 ml) was refluxed under heating for 5 hr. The reaction mixture was poured into water and extracted with ethyl acetate. The solvent was evaporated to give the title compound (4.6 g) as a pale-yellow oil.

Workup

  1. temperatureunder heating for 5 hr
  2. extractionextracted with ethyl acetate
  3. customThe solvent was evaporated

Sources & evidence

ORD record
ord-a92fe6dfaa444cee86fdb50f13484bbf
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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