2-Piperazinylpyrimidine dihydrochloride → HCID 11660360, compound

HRID 1282163Notes

Reaction equation

HRID 1282163 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([NH:12][C:13](=[O:15])[CH3:14])([CH3:11])[CH3:10])=[CH:5][CH:4]=1.Cl.Cl.[N:18]1[CH:23]=[CH:22][CH:21]=[N:20][C:19]=1[N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>>[CH3:10][C:9]([NH:12][C:13](=[O:15])[CH3:14])([C:6]1[CH:7]=[CH:8][C:3]([CH2:2][N:27]2[CH2:28][CH2:29][N:24]([C:19]3[N:18]=[CH:23][CH:22]=[CH:21][N:20]=3)[CH2:25][CH2:26]2)=[CH:4][CH:5]=1)[CH3:11]

Participants

3

Reactant 2

HCID 116802722-Piperazinylpyrimidine dihydrochlorideHCID 18423089N-(1-(4-chloromethylphenyl)-1-methylethyl)acetamide

Product 1

HCID 11660360HCID 11660360, compound

Procedure

By similar reaction and treatment to that in Example 1(5) using N-(1-(4-chloromethylphenyl)-1-methylethyl)acetamide instead of N-(4-chloromethylphenylmethyl)acetamide and 1-(2-pyrimidyl)piperazine dihydrochloride instead of phenylpiperazine, the title compound was obtained as white crystals, m.p.=137-138° C.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-9b16ff45fa4c46c38442e369e26ca02e
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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