2-Chloro-N,N-dimethylpyrimidin-4-amine → N-(4-((4-(4-(N,N-dimethylamino)pyrimidin-2-yl)piperazin-1-yl)methyl)phenylmethyl)acetamide

HRID 1282169Notes

Reaction equation

HRID 1282169 reaction equation
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([CH2:14][NH:15][C:16](=[O:18])[CH3:17])=[CH:10][CH:9]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:20]1[N:25]=[C:24]([N:26]([CH3:28])[CH3:27])[CH:23]=[CH:22][N:21]=1>>[CH3:27][N:26]([C:24]1[CH:23]=[CH:22][N:21]=[C:20]([N:4]2[CH2:5][CH2:6][N:1]([CH2:7][C:8]3[CH:9]=[CH:10][C:11]([CH2:14][NH:15][C:16](=[O:18])[CH3:17])=[CH:12][CH:13]=3)[CH2:2][CH2:3]2)[N:25]=1)[CH3:28]

Participants

3

Reactant 2

HCID 959752-Chloro-N,N-dimethylpyrimidin-4-amineHCID 18423078N-(4-((piperazin-1-yl)methyl)phenylmethyl)acetamide

Product 1

HCID 18423177N-(4-((4-(4-(N,N-dimethylamino)pyrimidin-2-yl)piperazin-1-yl)methyl)phenylmethyl)acetamide

Procedure

By similar reaction and treatment to that in Example 1(5) using N-(4-((piperazin-1-yl)methyl)phenylmethyl)acetamide obtained in Example 78(2) instead of N-(4-chloromethylphenylmethyl)acetamide and 2-chloro-4-(N,N-dimethylamino)pyrimidine instead of phenylpiperazine, the title compound was obtained as white crystals, m.p.=152-155° C.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-565ace82120444b59fe0cb35c24c6e1e
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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