1-(Thiazol-2-yl)piperazine → HCID 11696128, compound

HRID 1282170Notes

Reaction equation

HRID 1282170 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([NH:12][C:13](=[O:15])[CH3:14])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[S:16]1[CH:20]=[CH:19][N:18]=[C:17]1[N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[S:16]1[CH:20]=[CH:19][N:18]=[C:17]1[N:21]1[CH2:22][CH2:23][N:24]([CH2:2][C:3]2[CH:8]=[CH:7][C:6]([C:9]3([NH:12][C:13](=[O:15])[CH3:14])[CH2:11][CH2:10]3)=[CH:5][CH:4]=2)[CH2:25][CH2:26]1

Participants

3

Reactant 2

HCID 9118061-(Thiazol-2-yl)piperazineHCID 18423039N-(1-(4-chloromethylphenyl)cyclopropyl)acetamide

Product 1

HCID 11696128HCID 11696128, compound

Procedure

By similar reaction and treatment to that in Example 1(5) using N-(1-(4-chloromethylphenyl)cyclopropyl)acetamide obtained in Example 71(1) instead of N-(4-chloromethylphenylmethyl)acetamide and 1-(thiazol-2-yl)piperazine obtained in Example 81(1) instead of phenylpiperazine, the title compound was obtained as pale-yellow crystals, m.p.=184-185° C.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-9351b56c2d6b44788f1049476ea1899e
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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