Water → 1-(4,6-Diethoxypyrimidin-2-yl)piperazine

HRID 1282178Notes

Reaction equation

HRID 1282178 reaction equation
C([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:15]=[C:14]([O:16][CH2:17][CH3:18])[CH:13]=[C:12]([O:19][CH2:20][CH3:21])[N:11]=2)[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+].O>C(O)C>[CH2:17]([O:16][C:14]1[CH:13]=[C:12]([O:19][CH2:20][CH3:21])[N:11]=[C:10]([N:7]2[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]2)[N:15]=1)[CH3:18]

Participants

5

Reactant 3

HCID 962Water2×HCID 14798Sodium HydroxideHCID 184231661-Acetyl-4-(4,6-diethoxypyrimidin-2-yl)piperazine

Product 1

HCID 184231681-(4,6-Diethoxypyrimidin-2-yl)piperazineYield 103.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 1-acetyl-4-(4,6-diethoxypyrimidin-2-yl)piperazine (1.8 g) and sodium hydroxide (1.0 g) in ethanol (10 ml)—water (10 ml) was refluxed under heating for 11 hr. The reaction mixture was poured into water and extracted with chloroform. The extract was dried over anhydrous sodium sulfate and the solvent was evaporated to give the title compound (1.6 g) as a pale-brown oil.

Workup

  1. temperatureunder heating for 11 hr
  2. extractionextracted with chloroform
  3. dry with materialThe extract was dried over anhydrous sodium sulfate
  4. customthe solvent was evaporated

Sources & evidence

ORD record
ord-9a7758eb4dc1431b91c314b3e3acd718
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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