HCID 18423050, compound → HCID 18423172, compound

HRID 1282180Notes

Reaction equation

HRID 1282180 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:15]=[C:14](F)[CH:13]=[C:12]([F:17])[N:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[CH3:18][NH:19][CH3:20].C(O)C>>[C:1]([N:4]1[CH2:5][CH2:6][N:7]([C:10]2[N:11]=[C:12]([F:17])[CH:13]=[C:14]([N:19]([CH3:20])[CH3:18])[N:15]=2)[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 18423050HCID 18423050, compoundHCID 22184060Dimethylamine ethanol

Product 1

HCID 18423172HCID 18423172, compound

Procedure

1-Acetyl-4-(4,6-difluoropyrimidin-2-yl)piperazine (1.9 g) was dissolved in 12% dimethylamine-ethanol solution (30 ml) and the mixture was stirred at room temperature for 1 hr. The reaction mixture was concentrated under reduced pressure. Water was added to the residue and the mixture was extracted with ethyl acetate. The extract was washed with brine and dried over anhydrous sodium sulfate. The solvent was evaporated to give the title compound (2.1 g) as a yellow solid.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additionWater was added to the residue
  3. extractionthe mixture was extracted with ethyl acetate
  4. washThe extract was washed with brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. customThe solvent was evaporated

Sources & evidence

ORD record
ord-4645d9bdf4974fe59e40652d4b3a5c70
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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