反应详情

温度

100 °C

1-Acetyl-4-(6-(dimethylamino)-4-fluoropyrimidin-2-yl)piperazine (1.0 g) was dissolved in 12% dimethylamine-ethanol solution (30 ml) in an autoclave, and the mixture was stirred at 100° C. for 5 hr. The reaction mixture was concentrated under reduced pressure and chloroform was added to the reside. The chloroform solution was washed with brine and dried over anhydrous sodium sulfate. The solvent was evaporated to give the title compound (1.3 g) as a pale-yellow solid.

1. concentrationThe reaction mixture was concentrated under reduced pressure and chloroform
2. additionwas added to the reside
3. washThe chloroform solution was washed with brine
4. dry with materialdried over anhydrous sodium sulfate
5. customThe solvent was evaporated