HCID 18423172, compound → HCID 18423139, compound

HRID 1282181Notes

Reaction equation

HRID 1282181 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:15]=[C:14](F)[CH:13]=[C:12]([N:17]([CH3:19])[CH3:18])[N:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[CH3:20][NH:21][CH3:22].C(O)C>>[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:15]=[C:14]([N:21]([CH3:22])[CH3:20])[CH:13]=[C:12]([N:17]([CH3:19])[CH3:18])[N:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 18423172HCID 18423172, compoundHCID 22184060Dimethylamine ethanol

Product 1

HCID 18423139HCID 18423139, compound

Conditions

Temperature
100 °C

Procedure

1-Acetyl-4-(6-(dimethylamino)-4-fluoropyrimidin-2-yl)piperazine (1.0 g) was dissolved in 12% dimethylamine-ethanol solution (30 ml) in an autoclave, and the mixture was stirred at 100° C. for 5 hr. The reaction mixture was concentrated under reduced pressure and chloroform was added to the reside. The chloroform solution was washed with brine and dried over anhydrous sodium sulfate. The solvent was evaporated to give the title compound (1.3 g) as a pale-yellow solid.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure and chloroform
  2. additionwas added to the reside
  3. washThe chloroform solution was washed with brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customThe solvent was evaporated

Sources & evidence

ORD record
ord-941f17c5b6244065a220fa40606b3810
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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