反应详情

A solution of 1-acetyl-4-(4,6-bis(dimethylamino)pyrimidin-2-yl)piperazine (1.3 g) and sodium hydroxide (0.5 g) in ethanol (15 ml)—water (15 ml) was refluxed under heating for 9.5 hr. The reaction mixture was concentrated under reduced pressure, and ethyl acetate was added to the residue and the mixture was washed with brine. The organic layer was dried over anhydrous sodium sulfate and the solvent was evaporated to give the title compound (0.9 g) as a pale-brown oil.

1. temperatureunder heating for 9.5 hr
2. concentrationThe reaction mixture was concentrated under reduced pressure, and ethyl acetate
3. additionwas added to the residue
4. washthe mixture was washed with brine
5. dry with materialThe organic layer was dried over anhydrous sodium sulfate
6. customthe solvent was evaporated