Water → 1-(4-Dimethylamino-6-methoxypyrimidin-2-yl)piperazine

HRID 1282184Notes

Reaction equation

HRID 1282184 reaction equation
C([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:15]=[C:14](F)[CH:13]=[C:12]([N:17]([CH3:19])[CH3:18])[N:11]=2)[CH2:6][CH2:5]1)(=O)C.[CH3:20][O-:21].[Na+].O>CO>[CH3:19][N:17]([CH3:18])[C:12]1[CH:13]=[C:14]([O:21][CH3:20])[N:15]=[C:10]([N:7]2[CH2:6][CH2:5][NH:4][CH2:9][CH2:8]2)[N:11]=1

Participants

5

Reactant 3

HCID 962WaterHCID 10942334Sodium MethoxideHCID 184231721-Acetyl-4-(6-(dimethylamino)-4-fluoropyrimidin-2-yl)piperazine

Product 1

HCID 184231231-(4-Dimethylamino-6-methoxypyrimidin-2-yl)piperazineYield 123.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-Acetyl-4-(6-(dimethylamino)-4-fluoropyrimidin-2-yl)piperazine (1.0 g) obtained in Example 109(1) and sodium methoxide (1.1 g) were refluxed under heating in methanol (10 ml) for 28 hr. The reaction mixture was poured into water (100 ml) and extracted with chloroform. The extract was dried over anhydrous sodium sulfate and the solvent was evaporated to give the title compound (1.1 g) as a pale-yellow oil.

Workup

  1. extractionextracted with chloroform
  2. dry with materialThe extract was dried over anhydrous sodium sulfate
  3. customthe solvent was evaporated

Sources & evidence

ORD record
ord-c2502f4022f340b9874fe7bc99dc3eda
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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