HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 18423027, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-((4-(chloromethyl)phenyl)methyl)acetamide | HCID 15550682 | — |
| Reactant | 1-(5-Bromo-1,3-thiazol-2-yl)piperazine | HCID 18423006 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 18423027 | HCID 18423027 | 82.7% |
Reaction Steps
A solution of N-(4-chloromethylphenylmethyl)acetamide (0.9 g), 1-(5-bromothiazol-2-yl)piperazine (1.1 g) and potassium carbonate (0.9 g) in dimethylformamide (10 ml) was stirred at 70° C. for 9 hr. Water (100 ml) was poured into the reaction mixture to allow precipitation of crystals. The crystals were collected by filtration and washed with water to give the title compound (1.5 g) as yellow crystals, m.p.=160-163° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06455528B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-cfee12241c164bfab5c85e3ab6c8f4c2 |
| Source note | uspto-grants-2002_09 |