2-Piperazinylpyrimidine dihydrochloride → HCID 70034524, compound

HRID 1282189Notes

Reaction equation

HRID 1282189 reaction equation
[ClH:1].Cl.[N:3]1[CH:8]=[CH:7][CH:6]=[N:5][C:4]=1[N:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.[Cl:15][CH:16]([C:18]1[CH:23]=[CH:22][C:21]([CH2:24][NH:25][C:26](=[O:28])[CH3:27])=[CH:20][CH:19]=1)[CH3:17]>>[ClH:15].[ClH:1].[N:3]1[CH:8]=[CH:7][CH:6]=[N:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH:16]([C:18]2[CH:23]=[CH:22][C:21]([CH2:24][NH:25][C:26](=[O:28])[CH3:27])=[CH:20][CH:19]=2)[CH3:17])[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 116802722-Piperazinylpyrimidine dihydrochlorideHCID 18423036N-(4-(1-chloroethyl)phenylmethyl)acetamide

Product 1

HCID 70034524HCID 70034524, compound

Procedure

By similar reaction and treatment to that in Example 1(5) using 1-(2-pyrimidyl) piperazine dihydrochloride instead of phenylpiperazine and N-(4-(1-chloroethyl)phenylmethyl)acetamide instead of N-(4-chloromethylphenylmethyl) acetamide, the title compound was obtained as a yellow amorphous solid.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-ec8d4f439dd0446b8e107448eda28dc5
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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