2-Piperazinylpyrimidine dihydrochloride → N-(1-(4-(1-(4-(pyrimidin-2-yl)piperazin-1-yl)ethyl)phenyl)-1-methylethyl)acetamide

HRID 1282190Notes

Reaction equation

HRID 1282190 reaction equation
Cl.Cl.[N:3]1[CH:8]=[CH:7][CH:6]=[N:5][C:4]=1[N:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.Cl[CH:16]([C:18]1[CH:23]=[CH:22][C:21]([C:24]([NH:27][C:28](=[O:30])[CH3:29])([CH3:26])[CH3:25])=[CH:20][CH:19]=1)[CH3:17]>>[N:3]1[CH:8]=[CH:7][CH:6]=[N:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH:16]([C:18]2[CH:23]=[CH:22][C:21]([C:24]([NH:27][C:28](=[O:30])[CH3:29])([CH3:26])[CH3:25])=[CH:20][CH:19]=2)[CH3:17])[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 116802722-Piperazinylpyrimidine dihydrochlorideHCID 18423053N-(1-(4-(1-chloroethyl)phenyl)-1-methylethyl)acetamide

Product 1

HCID 18423079N-(1-(4-(1-(4-(pyrimidin-2-yl)piperazin-1-yl)ethyl)phenyl)-1-methylethyl)acetamide

Procedure

By similar reaction and treatment to that in Example 1(5) using 1-(2-pyrimidyl) piperazine dihydrochloride instead of phenylpiperazine and N-(1-(4-(1-chloroethyl)phenyl)-1-methylethyl)acetamide instead of N-(4-chloromethylphenylmethyl)acetamide, the title compound was obtained as a white amorphous solid.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-eaca9075d93144d3bdccb00d322d381a
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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